解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The aim of the present study was to investigate the expression of activin A in esophageal carcinoma and its association with tumor differentiation and metastasis. A total of 57 esophageal carcinoma patients and 36 controls were included in the current study. The mRNA and protein expression levels of activin A in esoph...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3248
更新日期:2015-07-01 00:00:00
abstract::The major aim of the present study was to develop an integrin receptor-targeted liposomal paclitaxel (PTX) to enhance the targeting specificity and therapeutic effect of PTX on hepatocellular carcinoma (HCC) cells. The specific Arg-Gly-Asp (RGD) ligand was conjugated to 1,2-distearoylphosphatidylethanolamine-polyethyl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3242
更新日期:2015-07-01 00:00:00
abstract::Src is a tyrosine kinase that is of significance in tumor biology. The present review focuses on Src, its molecular structure, and role in cancer, in addition to its expression and function in sarcoma. In addition, the feasibility of Src as a potential drug target for the treatment of sarcoma is also discussed. Previo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3184
更新日期:2015-07-01 00:00:00
abstract::Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is an established cancer stem cell marker and is a target gene of the Wnt/β-catenin signaling pathway, a critical pathway in the process of tumor initiation and growth. In the present study, the mRNA expression levels of LGR5, adenomatous polyposis col...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3144
更新日期:2015-06-01 00:00:00
abstract::Aquaporin 5 (AQP5), a water channel protein, is highly expressed in non-small cell lung cancer (NSCLC) tissues compared with adjacent normal tissues. AQP5 expression in lung cancer tissues is associated with a poor prognosis. The present study aimed to analyze the expression of AQP5 and investigate its role in primary...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3108
更新日期:2015-06-01 00:00:00
abstract::Cervical cancer is the third most common malignancy worldwide, accounting for 250,000 mortalities annually. Notch1, an important regulator of cell-fate decisions and differentiation, has been found to be overexpressed in certain types of cancer. However, the role of Notch1 in cervical carcinogenesis remains unclear. I...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3143
更新日期:2015-06-01 00:00:00
abstract::Endostar, a modified recombinant human endostatin, inhibits the growth of a variety of tumors by suppressing neovascularization. Vascular endothelial growth factor (VEGF) has an important role in malignant ascites formation. In order to determine whether Endostar can suppress the formation of ascites and prolong survi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3134
更新日期:2015-06-01 00:00:00
abstract::MicroRNAs are proposed to serve vital functions in the regulation of tumor progression and invasion. However, the expression levels of miR-203 in non-small cell lung cancer (NSCLC) and its clinical significance remain unknown. In the present study, the association between B-cell-specific moloney murine leukemia virus ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3080
更新日期:2015-06-01 00:00:00
abstract::The present study reports the rare case of a patient with quintuple primary cancer that underwent systematic treatment, including surgical intervention. A 63-year-old male patient was initially diagnosed with primary esophageal cancer and hypopharyngeal cancer. The patient underwent total pharyngolaryngoesophagectomy ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3082
更新日期:2015-06-01 00:00:00
abstract::The current study reports the case of a large retroperitoneal tumor treated with modified simultaneous integrated boost (SIB) radiotherapy. A 45-year-old female presented to the emergency department complaining of left abdominal pain and fever. A computed tomography scan detected a retroperitoneal tumor of 12×16×16 cm...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3095
更新日期:2015-06-01 00:00:00
abstract::Central diabetes insipidus (DI) is a rare complication in patients with acute myeloid leukemia (AML), typically occurring in patients with abnormalities of chromosomes 3 or 7. The association between AML with monosomy 7 and DI has been described in a number of studies; however, DI has been rarely reported in cases of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3139
更新日期:2015-06-01 00:00:00
abstract::Exophthalmos, myxedema and osteoarthropathy (EMO) comprise the triad known as EMO syndrome, which is rarely observed in patients with autoimmune thyroid disease. The present study reports the case of a patient with EMO, including the response of this rare combination to radiotherapy. A 48-year-old patient with EMO syn...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2990
更新日期:2015-05-01 00:00:00
abstract::Pancreatic cancer is one of the most frequently occurring malignancies worldwide and it is the fourth most common cause of cancer-associated mortality in Western countries. Thalidomide (THD) plays an important role in tumor therapy, as it is able to promote early stage apoptosis and inhibit the process of angiogenesis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3064
更新日期:2015-05-01 00:00:00
abstract::Hypermethylated in cancer 1 (HIC1) is a putative suppressor gene, cooperating with TP53 in the regulation of apoptosis. The promoter site of this gene contains CpG islands susceptible to methylation. Altered methylation leads to the silencing of HIC1. Persistent loss of HIC1 function reflects the attenuation of proapo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2983
更新日期:2015-05-01 00:00:00
abstract::The present study reviewed three patients with acute myeloid leukemia (AML) who had the specific genetic abnormality t(16;21)(p11;q22). To investigate the clinical and laboratory characteristics of AML with t(16;21)(p11;q22) translocation, the similarities and differences of clinical characteristics and laboratory exa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3051
更新日期:2015-05-01 00:00:00
abstract::We previously reported the case of a 56-year-old male who underwent surgical treatment for gastric hepatoid adenocarcinoma and splenic metastasis. The present study reports the case of the same patient who underwent successful ex vivo hepatectomy and partial liver autotransplantation. Computed tomography scans demonst...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3041
更新日期:2015-05-01 00:00:00
abstract::A 39-year-old female presented to The First Affiliated Hospital of Jishou University (Jishou, Hunan) with a fever of unknown origin and progressive abdominal distension. Physical examination revealed generalized lymphadenopathy, multiple non-tender cutaneous nodules, hepatomegaly, splenomegaly and abdominal edema. An ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3010
更新日期:2015-05-01 00:00:00
abstract::The present study aimed to examine the effectiveness of immunostaining of cytological specimens in discerning squamous from non-squamous cell carcinoma. Various combinations of six antibodies were examined in order to determine the optimal combination for use in differential diagnosis. Immunostaining was performed usi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3045
更新日期:2015-05-01 00:00:00
abstract::Fluoro-edenite is a natural mineral species initially isolated in Biancavilla, Sicily. The fibres are similar in size and morphology to certain amphibolic asbestos fibres, the inhalation of which may cause chronic inflammation and cancer. Occupational asbestos exposure is known to be associated with pleural and lung d...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2978
更新日期:2015-05-01 00:00:00
abstract::Metastasis-associated in colon cancer-1 (MACC1) is a gene that has been newly identified by a genome-wide search for differentially expressed genes in human colon cancer tissues, metastases and normal tissues. MACC1 exerts an important role in colon cancer metastasis through upregulation of the c-Met proto-oncogene. T...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2984
更新日期:2015-05-01 00:00:00
abstract::In order to examine the role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression for the prognostic evaluation of non-small cell lung carcinoma (NSCLC), a total of 186 breast cancer patients, with adjacent non-tumor lung tissues, were selected for immunohistochemical staining of IMP3 protein. The...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2910
更新日期:2015-04-01 00:00:00
abstract::Pulmonary inflammatory myofibroblastic tumors (PIMTs) are extremely rare in adults. If occurring in patients >40 years old, PIMT should be rapidly distinguished from lung cancer. The present study aimed to characterize the imaging features of PIMT in patients >40 years old in order to improve the diagnosis of PIMT. Th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2923
更新日期:2015-04-01 00:00:00
abstract::Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is currently approved in Japan for treatment of breast cancer. However, apart from phase I clinical trials, data regarding Japanese patients are scant. In the present study, the efficacy and safety of nab-paclitaxel therapy were retrospectively analyzed in 22 pati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2954
更新日期:2015-04-01 00:00:00
abstract::Cancer and embryo expression protein 65 (CEP65) is a centrosomal protein that is expressed at relatively high levels in embryonic tissue and different cancerous tissues, but its role in tumorigenesis remains unknown. In the present study, CEP65 was stably expressed in AGS gastric cancer cells. CEP65 was found to promo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2958
更新日期:2015-04-01 00:00:00
abstract::Angiosarcoma is a rare and deadly malignancy originating from the vascular endothelial cells. Surgery is the most effective method to cure this disease, but for metastatic angiosarcoma, a chemotherapy-based treatment is the main therapeutic choice. However, there is currently no standard chemotherapy regimen. The curr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2919
更新日期:2015-04-01 00:00:00
abstract::Mosquito coils, which are commonly used as residential insecticides in Asia, contain different concentrations of octachlorodipropyl ether (S-2) as a synergist or an active ingredient. As bis(chloromethyl) ether (BCME) is an extremely potent lung carcinogen that can be produced by the thermolytic degradation of S-2, co...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2922
更新日期:2015-04-01 00:00:00
abstract::The present study aimed to investigate the effects of the WW domain-containing oxidoreductase (WWOX) gene on the stem cell properties of human ovarian cancer stem cells. A eukaryotic expression vector containing the WWOX gene was transfected into human ovarian cancer stem cells and Western blotting was used to assess ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2971
更新日期:2015-04-01 00:00:00
abstract::Primary hepatic lymphoma (PHL) is an uncommon lymphoid tumor with varied clinical features and treatment outcome. In the present study, the case of a 56-year-old patient with PHL and no clinical presentation was reported. During a routine physical examination, multiple hypodense nodules were incidentally detected in r...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2920
更新日期:2015-04-01 00:00:00
abstract::Gastric cancer is one of leading causes of cancer-related mortality worldwide and is a notable disease due to its heterogeneity. Recently, numerous studies have investigated the molecular basis of gastric cancer, involving the alteration of pathogenesis, and invasion and metastasis. With the development of modern tech...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2959
更新日期:2015-04-01 00:00:00
abstract::The incidence of intussusception is low in adults, particularly in the descending colon, due to the anatomical attachment of the descending colon to the retroperitoneum. Signet ring cell histology represents ~1% of colon adenocarcinomas and is associated with young patients and a poor clinical outcome. The present stu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2805
更新日期:2015-03-01 00:00:00
abstract::Gastric cancer (GC) is the second leading cause of cancer-related mortality worldwide. The usual treatment of GC consists of surgery with additional adjuvant chemotherapy. In the present study, the feasibility and safety of adjuvant S-1 plus oxaliplatin (SOX) chemotherapy for patients with GC and the optimal dosage of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2821
更新日期:2015-03-01 00:00:00
abstract::Bone metastasis is an uncommon event in advanced gastric cancer patients and bone metastases are rarely detected as isolated lesions. However, eleven years after treatment for locally advanced gastric cancer, including total gastrectomy followed by adjuvant chemotherapy, a 49-year-old female was admitted to the IX Div...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2822
更新日期:2015-03-01 00:00:00
abstract::Reactive nodular fibrous pseudotumor (RNFP) is a tumor-like lesion that is characterized by reactive fibroblast/myofibroblast proliferation within collagenic hyalinized stroma, due to its association with injury or inflammation. The current study describes the case of a 60-year-old female with a history of abdominal s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2882
更新日期:2015-03-01 00:00:00
abstract::Penile cancer is an extremely rare form of urological cancer that usually originates in the epithelium of the inner preputium or glans. Major etiological factors include phimosis, poor penile hygiene and smoking. Nearly 95% of penile cancers are squamous cell carcinomas and usually occur in the sixth decade of life. T...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2839
更新日期:2015-03-01 00:00:00
abstract::The current study presents the case of a 68-year-old female patient who received biological intensity-modulated radiotherapy (BIMRT) and neoadjuvant chemotherapy for multiple peritoneal metastases of ovarian cancer. The International Federation of Gynecology and Obstetrics disease stage was IIIc. In addition, the pati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2820
更新日期:2015-03-01 00:00:00
abstract::The present study aimed to evaluate regional liver function impairment following transcatheter arterial chemoembolization (TACE), assessed by magnetic resonance imaging (MRI) enhanced by gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). Additionally, this study evaluated the associations betwe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2826
更新日期:2015-03-01 00:00:00
abstract::Hypoxic microenvironments and angiogenesis have been a focus of tumor research in previous years. The aim of the the present study was to create a hypoxic model and observe the effect of hypoxia on the expression of hypoxia inducible factor-1α (HIF-1α), insulin-like growth factor I (IGF-1) and vascular endothelial gro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2879
更新日期:2015-03-01 00:00:00
abstract::The incidence of synchronous multiple primary lung cancer (MPLC) is increasing. However, present diagnostic methods are unable to satisfy the individualized treatment requirements of patients with MPLC. The present study aimed to establish a quantitative mathematical model and analyze its diagnostic value for distingu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2880
更新日期:2015-03-01 00:00:00
abstract::The causes of lung cancer in never-smokers remain unclear. The potential contribution of human papillomavirus (HPV) to the carcinogenesis of non-small cell lung cancer (NSCLC) has been reported. In 2008, a prospective registry of never-smokers with NSCLC was established at the Kinki-Chuo Chest Medical Center, Sakai, O...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2713
更新日期:2015-02-01 00:00:00
abstract::A tissue-specific promoter can control downstream gene expression in tissues or organs. The human involucrin (hINV) promoter (pINV) that contains 2474 bp of hINV upstream sequence is able to regulate tissue-specific gene expression. This tissue specificity may be important for the prevention and treatment of human pap...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2736
更新日期:2015-02-01 00:00:00